Before treatment

An estimated 0.7% to 3% of the world population may have an allergic reaction to collagen of animal origins; our extensive testing shows that sensitivity to Salvecoll® occurs in less than 0.7% of patients. Patients without a history of hypersensitivity to Salvecoll® do not develop allergic reactions after subsequent repeated injections of the product.

Salvecoll® should not be used in the following cases:

  • If the patient develops a positive reaction to the skin test
  • The patient is allergic to collagen
  • The patient suffers from an autoimmune disorder (a disease arising from or affecting the tissues), including rheumatoid arthritis, systemic lupus erythematosus, scleroderma, Sjogren’s syndrome and dermatomyositis or polymyositis.
  • In the presence of tumors in close proximity to area of intervention.
  • The patient is undergoing chemotherapy, radiotherapy or immunosuppression treatment.

The use of Salvecoll® in combination with a synthetic filler is not recommended due to a possible increased risk of infection and topical inflammation. Occasionally migration of implanted materials can also be observed.

Use of Salvecoll® with other medication

Considering Salvecoll®’s properties of forming complexes with various active pharmacological substances (anti-inflammatory, antibacterial, antiviral, etc.), Salvecoll® can be used as a carrier for the transport of these substances with the probability of creating a barrier against the penetration of bacteria.

Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

Pregnancy and lactation

Salvecoll® gel should be only used during pregnancy if the benefits outweigh the risks.

Possible side effects

Like all implants, Salvecoll® can have side effects, although not everyone experiences them. The administration of Salvecoll® is a surgical procedure, thus, adverse events that may occur as a result of the surgery but are not necessarily associated with the gel itself may include:

  • Bleeding at the wound site
  • Non-healing wound
  • Wound infection
  • Nausea


  • Fever and pain
  • Rash
  • Cyanosis and edema

The following side effects may be associated with the use of Salvecoll®:

  • Discoloration of the wound
  • Erythema (skin redness)
  • Tenderness and swelling at the implant site

The following phenomena are not observed when using Salvecoll®:

  • Migration from the injection site
  • Granuloma formation
  • Skin pigmentation
  • Atrophy

Furthermore, over-correction is permissible and disappears without any intervention. Necrosis can occur only when the site being treated is infected.

After treatment

All necessary steps to be taken after treatment are to be discussed with your physician prior to treatment.