SALVECOLL in Practice


Salvecoll® is sterile bioplastic type I collagen material with a fully preserved fibrous structure (non-reconstructed) that ensures the regeneration of affected tissues. Type I collagen has zero risk of transmitting viral or microbial infections.

Salvecoll® can be obtained in bovine collagen form.

The highly innovative manufacturing technology of Salvecoll® allows:

  • Preservation of the full integrity of collagen fibers (triple-helix structure), thereby avoiding cross-linking
  • Formation of covalent intermolecular bonds
  • High structural stability indexes.

Before Injection
After Injection
After 3 months
After 6 months

When Salvecoll® gel is injected into the dermis or other damaged tissues, fibroblasts and other non-resident cells begin to migrate from the surrounding tissues and invade the collagen gel. Additionally, the injection has the immediate effect of mechanically filling the defects, then a transition matrix is formed at the site of the Salvecoll® gel injection (aseptic inflammation), which stimulates the immune system and activation of granulocytes, macrophages and fibroblasts, accompanied by enhanced transport of growth factors released from cells, which in turn leads to increased migration and proliferation of fibroblasts and epithelial cells. The purpose of the collagen gel is to provide a matrix for the cells, allowing them to form new tissue. The fibroblasts produce new collagen fibers at the site of the gel injection and the gel itself is gradually degraded by collagenase enzymes produced by fibroblasts, and replaced by autologous human collagen, synthesized de novo.

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